Randall L. Davis, Ph.D.
Associate Professor of Pharmacology
Texas Tech University
Oklahoma State University
B.S. (Biomedical Sciences)
Oklahoma State University
NRSA (NIAAA/NIH) Postdoctoral Fellow, Texas Tech University HSC (Pharmacology & Neuroscience).
Postdoctoral Research Associate, Texas Tech University HSC (Pharmacology)
NIH/NIAAA 4/01/2002 – 9/30/2004
NIH/NIAAA 5/01/2006 – 4/30/2008
NIH/NINDS 8/01/2008 – 6/30/2011 no-cost extension until 6/30/2012
Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: Evidence for a transcriptional mechanism. R.L. Davis, P.J. Syapin. Alcohol 32(3):195-202; 2004.
Ethanol increases nuclear factor-kB p65 activity in human astroglia. R.L. Davis, P.J. Syapin. Neuroscience Letters 371:128-132; 2004.
Effects of mechanistically distinct NF-kB inhibitors on glial inducible nitric-oxide synthase expression. R.L. Davis, A.C. Sanchez, D.J. Lindley, P.J. Syapin. Nitric Oxide 12: 200-209; 2005.
Interactions of alcohol and nitric-oxide synthase in the brain. R.L. Davis and P.J. Syapin. Brain Research Reviews 49: 494-504; 2005.
The opioid antagonist, β-funaltrexamine, inhibits chemokine expression in human astroglial cells. R.L. Davis, D. Buck, N. Saffarian, C.W. Stevens. Journal of Neuroimmunology 186:141-149; 2007.
The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells. A.C. Sanchez, R.L. Davis, P.J. Syapin. Brain Research 1179:16-27; 2007.
β-Funaltrexamine inhibits inducible nitric-oxide synthase expression in human astroglial cells. R.L. Davis, D.J. Buck, N.Saffarian, S. Mohan, U. Desilva, S.C. Fernando, C.W. Stevens. Journal of Neuroimmune Pharmacology 3:150-153; 2008.
Importance of alcohol induced modulation of nitric-oxide synthase in the brain. R.L. Davis and P.J. Syapin. In Research on the Neurobiology of Alcohol Use Disorders. (L. Sher, Ed.), Nova Science, New York (2008).
Pro-inflammatory cytokines and HIV-1 synergistically enhance CXCL10 expression in human astrocytes. R. Williams, N.K. Dhillon, S.T. Hedge, H. Yao, S. Callen, F. Peng, Y. Chebloune, R.L. Davis, S.J. Buch. Glia 57:734-743; 2009.
Dual regulation of mu opioid receptors in SK-N-SH neuroblastoma cells by morphine and interleukin-1β: evidence for opioid-immune crosstalk. S. Mohan, R.L. Davis, U. DeSilva, C.W. Stevens. Journal of Neuroimmunology 227:26-34; 2010.
Inorganic mercury exposure in prairie vole (Microtus ochrogaster) alters the expression of toll-like receptor 4 and activates inflammatory pathways in the liver in a sex-specific manner. Senait, A., J.T. Curtis, S. Sethi, R.L. Davis, Y. Chen, R. Kaul.Human & Experimental Toxicology (2012, Epub ahead of print; in press).
Neuroinflammation: My lab is interested in gaining a better understanding of neuroimmune signaling in CNS disorders such as HIV Dementia, Parkinson’s disease, and Autism. Additionally, we are interested in identifying the mechanism by which pharmacologic agents such as opioids modulate neuroimmune signaling in astrocytes and microglia.
Soccer and Golf